Title : The clinical relevance of multiple DPYD polymorphisms on patients candidate for fluoropyrimidine based-chemotherapy. An Italian case-control study.

Pub. Date : 2019 Apr

PMID : 30858516






1 Functional Relationships(s)
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1 BACKGROUND: Deleterious polymorphisms in the gene encoding DPD (DPYD) may result in severe reduction of DPD enzymatic activity that causes life-threatening toxicities when the standard dose of fluorouracil is used. Fluorouracil dihydropyrimidine dehydrogenase Homo sapiens