Pub. Date : 2019 Jun
PMID : 30811219
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NGI-1 is a small-molecule inhibitor of oligosaccharyltransferase (OST) complexes STT3A-OST and STT3B-OST, which catalyze cotranslational and post-translational N-glycosylation, respectively. | Nitrogen | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Homo sapiens |
| 2 | NGI-1 is a small-molecule inhibitor of oligosaccharyltransferase (OST) complexes STT3A-OST and STT3B-OST, which catalyze cotranslational and post-translational N-glycosylation, respectively. | Nitrogen | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Homo sapiens |
| 3 | NGI-1 is a small-molecule inhibitor of oligosaccharyltransferase (OST) complexes STT3A-OST and STT3B-OST, which catalyze cotranslational and post-translational N-glycosylation, respectively. | Nitrogen | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Homo sapiens |
| 4 | N-glycosylation of 2 representative envelope proteins (gC and gD) was primarily dependent upon STT3A-OST, but to a large extent replaceable by STT3B-OST. | Nitrogen | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Homo sapiens |
| 5 | N-glycosylation of 2 representative envelope proteins (gC and gD) was primarily dependent upon STT3A-OST, but to a large extent replaceable by STT3B-OST. | Nitrogen | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Homo sapiens |
| 6 | However, with cells lacking STT3B-OST activity (missing the catalytic subunit STT3B or the oxidoreductase subunits magnesium transporter 1/tumor suppressor candidate 3) and thus solely dependent upon STT3A-OST for N-glycosylation, NGI-1 treatment resulted in HSV-1 having cell type-dependent dysfunction (affecting infectivity with Vero cells much more than with the 293 lines). | Nitrogen | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | Homo sapiens |