Pub. Date : 2019 May 1
PMID : 30794283
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cooperative effects of sequential PGF2alpha and IL-1beta on IL-6 and COX-2 expression in human myometrial cells . | Dinoprost | interleukin 6 | Homo sapiens |
| 2 | Sequential stimulation of HMSMC by PGF2alpha and IL-1beta in either order results in amplified upregulation of IL-6 and COX-2 mRNA and protein, compared to their effects individually. | Dinoprost | interleukin 6 | Homo sapiens |
| 3 | These results suggest that PGF2alpha and IL-1beta act cooperatively upstream in the birth cascade to maximize amplification of IL-6 and COX-2, to build inflammatory load and thereby promote uterine transition. | Dinoprost | interleukin 6 | Homo sapiens |
| 4 | Targeting PGF2alpha or IL-1beta, their actions, or intermediates (e.g. IL-6) would be an effective therapeutic intervention for preterm birth prevention or delay. | Dinoprost | interleukin 6 | Homo sapiens |