PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30794283-0 2019 Cooperative effects of sequential PGF2alpha and IL-1beta on IL-6 and COX-2 expression in human myometrial cells . Dinoprost 34-43 interleukin 6 Homo sapiens 60-64 30794283-5 2019 Sequential stimulation of HMSMC by PGF2alpha and IL-1beta in either order results in amplified upregulation of IL-6 and COX-2 mRNA and protein, compared to their effects individually. Dinoprost 35-44 interleukin 6 Homo sapiens 111-115 30794283-7 2019 These results suggest that PGF2alpha and IL-1beta act cooperatively upstream in the birth cascade to maximize amplification of IL-6 and COX-2, to build inflammatory load and thereby promote uterine transition. Dinoprost 27-36 interleukin 6 Homo sapiens 127-131 30794283-8 2019 Targeting PGF2alpha or IL-1beta, their actions, or intermediates (e.g. IL-6) would be an effective therapeutic intervention for preterm birth prevention or delay. Dinoprost 10-19 interleukin 6 Homo sapiens 71-75