Pub. Date : 2019 Jun
PMID : 30714195
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 2 | Molecular dynamics (MD) simulations and molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) calculations were employed to investigate the central step of the activation of Cdc42: the dissociation mechanism of GDP from Cdc42 via DOCK9. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 3 | Molecular dynamics (MD) simulations and molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) calculations were employed to investigate the central step of the activation of Cdc42: the dissociation mechanism of GDP from Cdc42 via DOCK9. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 4 | In the GDP dissociation process, the Mg2+ ion leave first to result in a suitable conformation of Cdc42 for following DOCK9 binding to. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 5 | When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 6 | When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 7 | When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 8 | When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 9 | When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 10 | When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 11 | This study first elucidates the dissociation mechanism of GDP from Cdc42 via DOCK9 and identifies the essential residues of Cdc42 in this process. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |
| 12 | This study first elucidates the dissociation mechanism of GDP from Cdc42 via DOCK9 and identifies the essential residues of Cdc42 in this process. | Guanosine Diphosphate | cell division cycle 42 | Homo sapiens |