CPRiL

CDC42

cell division cycle 42

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

• cell division control protein 42 homolog
• G25K GTP-binding protein
• GTP binding protein, 25kDa
dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
growth-regulating protein
small GTP binding protein CDC42
CDC42Hs
G25K
TKS