Protein Name cell division cycle 42
Organism Homo sapiens
Gene ID 998
Gene Symbol


UniProt P60953 (CDC42_HUMAN), A0A024RAA5 (A0A024RAA5_HUMAN), A0A024RAE6 (A0A024RAE6_HUMAN)
Relationships Total Number of functionally related compound(s) : 455
Total Number of Articles : 893

cell division cycle 42

Gene Summary

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

  • cell division control protein 42 homolog
  • G25K GTP-binding protein
  • GTP binding protein, 25kDa
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