PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30714195-0 2019 Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations. Guanosine Diphosphate 26-29 cell division cycle 42 Homo sapiens 35-40 30714195-6 2019 Molecular dynamics (MD) simulations and molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) calculations were employed to investigate the central step of the activation of Cdc42: the dissociation mechanism of GDP from Cdc42 via DOCK9. Guanosine Diphosphate 218-221 cell division cycle 42 Homo sapiens 181-186 30714195-6 2019 Molecular dynamics (MD) simulations and molecular mechanics-Poisson-Boltzmann surface area (MM-PBSA) calculations were employed to investigate the central step of the activation of Cdc42: the dissociation mechanism of GDP from Cdc42 via DOCK9. Guanosine Diphosphate 218-221 cell division cycle 42 Homo sapiens 227-232 30714195-8 2019 In the GDP dissociation process, the Mg2+ ion leave first to result in a suitable conformation of Cdc42 for following DOCK9 binding to. Guanosine Diphosphate 7-10 cell division cycle 42 Homo sapiens 98-103 30714195-9 2019 When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. Guanosine Diphosphate 151-154 cell division cycle 42 Homo sapiens 20-25 30714195-9 2019 When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. Guanosine Diphosphate 151-154 cell division cycle 42 Homo sapiens 100-105 30714195-9 2019 When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. Guanosine Diphosphate 151-154 cell division cycle 42 Homo sapiens 100-105 30714195-9 2019 When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. Guanosine Diphosphate 166-169 cell division cycle 42 Homo sapiens 20-25 30714195-9 2019 When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. Guanosine Diphosphate 166-169 cell division cycle 42 Homo sapiens 100-105 30714195-9 2019 When DOCK9 binds to Cdc42, it changes the orientations of residues Lys16, Thr17, Cys18 and Phe28 of Cdc42 to weaken the interactions between Cdc42 and GDP to release GDP. Guanosine Diphosphate 166-169 cell division cycle 42 Homo sapiens 100-105 30714195-10 2019 This study first elucidates the dissociation mechanism of GDP from Cdc42 via DOCK9 and identifies the essential residues of Cdc42 in this process. Guanosine Diphosphate 58-61 cell division cycle 42 Homo sapiens 67-72 30714195-10 2019 This study first elucidates the dissociation mechanism of GDP from Cdc42 via DOCK9 and identifies the essential residues of Cdc42 in this process. Guanosine Diphosphate 58-61 cell division cycle 42 Homo sapiens 124-129