Pub. Date : 2019 Feb 19
PMID : 30676743
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study investigated the interaction of recombinant CYP3A4 with a nonspecific inhibitor metyrapone, antifungal drug fluconazole, and protease inhibitor phenylmethanesulfonyl fluoride (PMSF). | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Metyrapone and fluconazole are classic type II ligands that inhibit CYP3A4 with medium strength by ligating to the heme iron, whereas PMSF, lacking the heme-ligating moiety, acts as a weak type I ligand and inhibitor of CYP3A4. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Metyrapone and fluconazole are classic type II ligands that inhibit CYP3A4 with medium strength by ligating to the heme iron, whereas PMSF, lacking the heme-ligating moiety, acts as a weak type I ligand and inhibitor of CYP3A4. | Metyrapone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |