PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30676743-2 2019 This study investigated the interaction of recombinant CYP3A4 with a nonspecific inhibitor metyrapone, antifungal drug fluconazole, and protease inhibitor phenylmethanesulfonyl fluoride (PMSF). Metyrapone 91-101 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 55-61 30676743-3 2019 Metyrapone and fluconazole are classic type II ligands that inhibit CYP3A4 with medium strength by ligating to the heme iron, whereas PMSF, lacking the heme-ligating moiety, acts as a weak type I ligand and inhibitor of CYP3A4. Metyrapone 0-10 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 68-74 30676743-3 2019 Metyrapone and fluconazole are classic type II ligands that inhibit CYP3A4 with medium strength by ligating to the heme iron, whereas PMSF, lacking the heme-ligating moiety, acts as a weak type I ligand and inhibitor of CYP3A4. Metyrapone 0-10 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 220-226