Title : Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways.

Pub. Date : 2019 Feb

PMID : 30597292






3 Functional Relationships(s)
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1 Rosmarinic acid protects mice from lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-kappaB and activating Nrf2/HO-1 signaling pathways. rosmarinic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Our findings showed that RA could protect C57BL/6 mice from LPS/d-GalN-induced acute liver injury, which not only reflected on declining aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of the serum, but also restrained the phosphorylation of nuclear factor-kappa B (NF-kappaB), extracellular signal-regulated kinase (ERK1/2) and p38 protein expression and the content of tissue myeloperoxidase (MPO) elevation. rosmarinic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 Our findings showed that RA could protect C57BL/6 mice from LPS/d-GalN-induced acute liver injury, which not only reflected on declining aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of the serum, but also restrained the phosphorylation of nuclear factor-kappa B (NF-kappaB), extracellular signal-regulated kinase (ERK1/2) and p38 protein expression and the content of tissue myeloperoxidase (MPO) elevation. rosmarinic acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus