Pub. Date : 2019 Mar 1
PMID : 30593501
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We observed that Grx1 reduces GSH-containing disulfides (including oxidized trypanothione) in very fast reactions (k > 5 x 105 m-1 s-1). | Disulfides | glutaredoxin | Homo sapiens |
2 | This kinetic selectivity in the reduction step of the catalytic cycle suggests that Grx1 uses preferentially a dithiol mechanism, forming a disulfide on the active site during the oxidative half of the catalytic cycle and then being rapidly reduced by T(SH)2 in the reductive half. | Disulfides | glutaredoxin | Homo sapiens |