Title : Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites.

Pub. Date : 2019 Mar 1

PMID : 30593501






2 Functional Relationships(s)
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Protein Name
Organism
1 We observed that Grx1 reduces GSH-containing disulfides (including oxidized trypanothione) in very fast reactions (k > 5 x 105 m-1 s-1). Disulfides glutaredoxin Homo sapiens
2 This kinetic selectivity in the reduction step of the catalytic cycle suggests that Grx1 uses preferentially a dithiol mechanism, forming a disulfide on the active site during the oxidative half of the catalytic cycle and then being rapidly reduced by T(SH)2 in the reductive half. Disulfides glutaredoxin Homo sapiens