| Protein Name | glutaredoxin |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2745 |
| Gene Symbol | GLRX |
| UniProt | P35754 (GLRX1_HUMAN), A0A024RAM2 (A0A024RAM2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
262
Total Number of Articles : 365 |
Description |
glutaredoxin |
| Gene Summary |
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] |
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| Properties | |