Title : NF-κB and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells.

Pub. Date : 2019 Mar

PMID : 30559256






1 Functional Relationships(s)
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1 IMPLICATIONS: RELA and PARP1 form a positive feedback loop to regulate DNA damage repair, simultaneous inhibition of NF-kappaB and PARP1 increases the antileukemic efficacy of daunorubicin in vitro and in vivo, broadening the use of PARP1 inhibitors. Daunorubicin nuclear factor kappa B subunit 1 Homo sapiens