Pub. Date : 2019 Feb
PMID : 30362049
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NaB treatment increased the formation of autolysosome and expression of phosphorylated liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC). | nab | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | NaB treatment increased the formation of autolysosome and expression of phosphorylated liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC). | nab | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | Treatment with compound C (an inhibitor of AMPK) and siRNA-mediated knockdown of AMPK and LKB1 significantly attenuated NaB-induced autophagy in CRC cells. | nab | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | Collectively, these findings indicated that LKB1 and AMPK are critical for NaB-mediated autophagy and may act as the novel targets for colorectal cancer therapy in the future. | nab | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |