Pub. Date : 2019 Mar
PMID : 30317648
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that exogenous cholesterol significantly inhibited alkaline phosphatase (ALP) activity and messenger RNA expression of osteoblast markers genes (Alpl, Sp7, and Ibsp) while modestly activating expression of Gli1 (a readout of Hh signaling) under both basal osteogenic culture condition and Wnt3a treatment. | Cholesterol | GLI family zinc finger 1 | Homo sapiens |
| 2 | Similarly, exogenous cholesterol suppressed osteogenic response of ST2 cells to sonic Hh (Shh) or purmorphamine (Purmo) treatment, which, however, was accompanied by diminished induction of Gli1, indicating the involvement of a Hh-dependent mechanism. | Cholesterol | GLI family zinc finger 1 | Homo sapiens |
| 3 | Interestingly, depletion of endogenous cholesterol also reduced Shh-induced ALP activity and Gli1 expression. | Cholesterol | GLI family zinc finger 1 | Homo sapiens |