PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3026330-1	1986	Thrombin inhibits adenylate cyclase and stimulates GTP hydrolysis by high-affinity GTPase(s) in membranes of human platelets at almost identical concentrations.	Guanosine Triphosphate	51-54	coagulation factor II, thrombin	Homo sapiens	0-8	
3026330-3	1986	However, stimulation of GTP hydrolysis caused by adrenaline (alpha 2-adrenoceptor agonist) and by thrombin at maximally effective concentrations was partially additive, whereas with regard to adenylate cyclase inhibition no additive response was observed.	Guanosine Triphosphate	24-27	coagulation factor II, thrombin	Homo sapiens	98-106	
3026330-5	1986	Additionally, the thiol reagent N-ethylmalemide (NEM) at rather low concentrations abolished thrombin- and adrenaline-induced stimulation of GTP hydrolysis was decreased by only 30-40% by treatment of platelet membranes with even high concentrations of NEM.	Guanosine Triphosphate	141-144	coagulation factor II, thrombin	Homo sapiens	93-101	
3026330-7	1986	The data suggest that thrombin interaction with its receptor sites in platelet membranes leads to stimulation of two GTP-hydrolysing enzymes.	Guanosine Triphosphate	117-120	coagulation factor II, thrombin	Homo sapiens	22-30	
3026330-9	1986	The other GTP-hydrolysing enzyme activated by thrombin may represent a guanine nucleotide-binding protein apparently involved in the coupling of thrombin receptors to the phosphoinositide phosphodiesterase.	Guanosine Triphosphate	10-13	coagulation factor II, thrombin	Homo sapiens	46-54	
3026330-9	1986	The other GTP-hydrolysing enzyme activated by thrombin may represent a guanine nucleotide-binding protein apparently involved in the coupling of thrombin receptors to the phosphoinositide phosphodiesterase.	Guanosine Triphosphate	10-13	coagulation factor II, thrombin	Homo sapiens	145-153