Pub. Date : 2018 Nov
PMID : 30251691
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ALA treatment could increase H2S level, which reduced the autophagy-related index and activation of the 5"-monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway, thereby protecting vascular function in rats with T2DM. | Thioctic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | The protective effect of NaHS or ALA was attenuated by rapamycin (an autophagy activator), 5-amino-1-beta-d-ribofuranosyl-imidazole-4-carboxamide (an AMPK activator) or PPG. | Thioctic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | In contrast, Compound C (an AMPK inhibitor) enhanced the effect of ALA or NaHS. | Thioctic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | ALA may have a protective effect on VSMCs in T2DM by elevating H2S level and downregulating autophagy via the AMPK/mTOR pathway. | Thioctic Acid | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |