Pub. Date : 2018 Oct 15
PMID : 30249603
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It subsequently delineates how beta2 adrenergic receptor (beta2 AR) signaling via adenylyl cyclase and the cAMP-dependent protein kinase PKA is organized within nanodomains. | Cyclic AMP | adrenoceptor beta 2 | Homo sapiens |
| 2 | Here, we discuss targeting of beta2 AR, adenylyl cyclase, and PKA to defined signaling complexes at postsynaptic sites, i.e., AMPARs and the L-type Ca2+ channel Cav1.2, and other subcellular surface localizations, the role of A kinase anchor proteins, the physiological relevance of the spatial restriction of corresponding signaling, and their interplay with signal transduction by the Ca2+- and calmodulin-dependent kinase CaMKII How localized and specific signaling by cAMP occurs is a central cellular question. | Cyclic AMP | adrenoceptor beta 2 | Homo sapiens |