Title : Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling.

Pub. Date : 2018 Oct 15

PMID : 30249603

2 Functional Relationships(s)
Compound Name
Protein Name
1 It subsequently delineates how beta2 adrenergic receptor (beta2 AR) signaling via adenylyl cyclase and the cAMP-dependent protein kinase PKA is organized within nanodomains. Cyclic AMP adrenoceptor beta 2 Homo sapiens
2 Here, we discuss targeting of beta2 AR, adenylyl cyclase, and PKA to defined signaling complexes at postsynaptic sites, i.e., AMPARs and the L-type Ca2+ channel Cav1.2, and other subcellular surface localizations, the role of A kinase anchor proteins, the physiological relevance of the spatial restriction of corresponding signaling, and their interplay with signal transduction by the Ca2+- and calmodulin-dependent kinase CaMKII How localized and specific signaling by cAMP occurs is a central cellular question. Cyclic AMP adrenoceptor beta 2 Homo sapiens