| Protein Name | adrenoceptor beta 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 154 |
| Gene Symbol | ADRB2 |
| UniProt | P07550 (ADRB2_HUMAN), X5DQM5 (X5DQM5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
772
Total Number of Articles : 2067 |
Description |
adrenoceptor beta 2 |
| Gene Summary |
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019] |
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