Protein Name adrenoceptor beta 2
Organism Homo sapiens
Gene ID 154
Gene Symbol


UniProt P07550 (ADRB2_HUMAN), X5DQM5 (X5DQM5_HUMAN)
Relationships Total Number of functionally related compound(s) : 772
Total Number of Articles : 2067

adrenoceptor beta 2

Gene Summary

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]

  • beta-2 adrenergic receptor
  • adrenergic, beta-2-, receptor, surface
  • adrenoceptor beta 2 surface
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