Pub. Date : 2018 Sep
PMID : 30178440
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The influences of CYP2C9*1/*3 genotype on the pharmacokinetics of zolpidem. | Zolpidem | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Zolpidem is predominantly metabolized by CYP3A4, and to a lesser extent by CYP2C9, CYP1A2, CYP2D6 and CYP2C19. | Zolpidem | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | The aim of this study was to identify the effects of CYP2C9*3 allele on the pharmacokinetics of zolpidem. | Zolpidem | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | In addition, since zolpidem is metabolized at a high rate by CYP3A4, the effect of CYP2C9*3 allele on the pharmacokinetics of zolpidem was also observed in the condition where CYP3A4 was sufficiently inhibited by the steady-state concentration of clarithromycin, a potent CYP3A4 inhibitor. | Zolpidem | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | In addition, since zolpidem is metabolized at a high rate by CYP3A4, the effect of CYP2C9*3 allele on the pharmacokinetics of zolpidem was also observed in the condition where CYP3A4 was sufficiently inhibited by the steady-state concentration of clarithromycin, a potent CYP3A4 inhibitor. | Zolpidem | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |