Pub. Date : 2018 Sep 1
PMID : 30176331
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxime HI-6 50 mg/kg reactivated acetylcholinesterase (AChE) in brain inhibited by physostigmine and in diaphragm inhibited by pyridostigmine. | Physostigmine | acetylcholinesterase | Rattus norvegicus |
| 2 | CONCLUSIONS: Mechanism of physostigmine-induced lethal effect is predominantly central and it involves inhibition of brain AChE, while pyridostigmine produces the same effect exclusively outside the central nervous system, by inhibiting AChE in the respiratory muscles. | Physostigmine | acetylcholinesterase | Rattus norvegicus |
| 3 | CONCLUSIONS: Mechanism of physostigmine-induced lethal effect is predominantly central and it involves inhibition of brain AChE, while pyridostigmine produces the same effect exclusively outside the central nervous system, by inhibiting AChE in the respiratory muscles. | Physostigmine | acetylcholinesterase | Rattus norvegicus |
| 4 | The oxime acts as antidote against physostigmine and pyridostigmine poisoning by reactivating AChE in the brain and diaphragm, respectively. | Physostigmine | acetylcholinesterase | Rattus norvegicus |