PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30176331-11	2018	Oxime HI-6 50 mg/kg reactivated acetylcholinesterase (AChE) in brain inhibited by physostigmine and in diaphragm inhibited by pyridostigmine.	Physostigmine	82-95	acetylcholinesterase	Rattus norvegicus	54-58	
30176331-12	2018	CONCLUSIONS: Mechanism of physostigmine-induced lethal effect is predominantly central and it involves inhibition of brain AChE, while pyridostigmine produces the same effect exclusively outside the central nervous system, by inhibiting AChE in the respiratory muscles.	Physostigmine	26-39	acetylcholinesterase	Rattus norvegicus	123-127	
30176331-12	2018	CONCLUSIONS: Mechanism of physostigmine-induced lethal effect is predominantly central and it involves inhibition of brain AChE, while pyridostigmine produces the same effect exclusively outside the central nervous system, by inhibiting AChE in the respiratory muscles.	Physostigmine	26-39	acetylcholinesterase	Rattus norvegicus	237-241	
30176331-14	2018	The oxime acts as antidote against physostigmine and pyridostigmine poisoning by reactivating AChE in the brain and diaphragm, respectively.	Physostigmine	35-48	acetylcholinesterase	Rattus norvegicus	94-98