Pub. Date : 2019 Jan
PMID : 30157131
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. | Cannabidiol | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 2 | Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. | Cannabidiol | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 3 | Repeated treatment with CBD (5 mg/kg/day, subcutaneously [s.c.], for 7 days) increased 5-HT firing through desensitization of 5-HT1A receptors. | Cannabidiol | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 4 | Overall, repeated treatment with low-dose CBD induces analgesia predominantly through TRPV1 activation, reduces anxiety through 5-HT1A receptor activation, and rescues impaired 5-HT neurotransmission under neuropathic pain conditions. | Cannabidiol | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |