PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30157131-1 2019 Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. Cannabidiol 31-42 5-hydroxytryptamine receptor 1A Rattus norvegicus 121-148 30157131-1 2019 Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. Cannabidiol 44-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 121-148 30157131-7 2019 Repeated treatment with CBD (5 mg/kg/day, subcutaneously [s.c.], for 7 days) increased 5-HT firing through desensitization of 5-HT1A receptors. Cannabidiol 24-27 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-132 30157131-11 2019 Overall, repeated treatment with low-dose CBD induces analgesia predominantly through TRPV1 activation, reduces anxiety through 5-HT1A receptor activation, and rescues impaired 5-HT neurotransmission under neuropathic pain conditions. Cannabidiol 42-45 5-hydroxytryptamine receptor 1A Rattus norvegicus 128-134