| Protein Name | 5-hydroxytryptamine receptor 1A |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24473 |
| Gene Symbol | Htr1a |
| UniProt | P19327 (5HT1A_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
1005
Total Number of Articles : 2244 |
Description |
5-hydroxytryptamine receptor 1A |
| Gene Summary |
Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and behavioral response to nicotine. Located in axon hillock. Is active in GABA-ergic synapse and presynaptic membrane. Used to study Parkinson's disease; alcohol use disorder; and panic disorder. Biomarker of anxiety disorder; cocaine abuse; nicotine dependence; and subacute delirium. Human ortholog(s) of this gene implicated in alcohol dependence; anxiety disorder (multiple); depressive disorder; substance abuse; and withdrawal disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Jun 2025] |
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