Title : Effects of insulin-like growth factor-1 on endoplasmic reticulum stress and autophagy in rat gastric smooth muscle cells cultured at different glucose concentrations in vitro.

Pub. Date : 2019 Jan

PMID : 30008033






4 Functional Relationships(s)
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1 Twenty-four hours after cells were cultured at different glucose concentrations in vitro, expression of GRP78, CHOP, and LC3II/I was significantly higher in the high glucose-treated group compared with the normal glucose group (p < 0.05). Glucose DNA-damage inducible transcript 3 Rattus norvegicus
2 Twenty-four hours after cells were cultured at different glucose concentrations in vitro, expression of GRP78, CHOP, and LC3II/I was significantly higher in the high glucose-treated group compared with the normal glucose group (p < 0.05). Glucose DNA-damage inducible transcript 3 Rattus norvegicus
3 After IGF-1 intervention, CHOP and GRP78 expression were significantly higher in the normal glucose + IGF-1 group compared with the normal glucose group (p < 0.01), while no significant difference was found between high glucose and high glucose + IGF-1 groups. Glucose DNA-damage inducible transcript 3 Rattus norvegicus
4 However, CHOP and GRP78 expression were significantly lower in the high glucose + IGF-1 group compared with the high glucose group (p < 0.05). Glucose DNA-damage inducible transcript 3 Rattus norvegicus