Protein Name DNA-damage inducible transcript 3
Organism Rattus norvegicus
Gene ID 29467
Gene Symbol

Ddit3

UniProt Q496Y7 (Q496Y7_RAT), Q62804 (Q62804_RAT)
Relationships Total Number of functionally related compound(s) : 340
Total Number of Articles : 468
Description

DNA-damage inducible transcript 3

Gene Summary

Enables DNA-binding transcription factor activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of autophagy in response to ER overload; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of CHOP-C/EBP complex. Biomarker of several diseases, including borna disease; brain ischemia; chronic obstructive pulmonary disease; pulmonary venoocclusive disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • DNA damage-inducible transcript 3 protein
  • C/EBP homologous protein
  • C/EBP zeta
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Properties