Pub. Date : 2018 Jul
PMID : 29971135
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia exposure induced cisplatin resistance partially via activating p53 and hypoxia inducible factor-1alpha in non-small cell lung cancer A549 cells. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | In the present study, the effects of hypoxia on the response of the NSCLC A549 cell line to the clinically relevant cytotoxic cisplatin were evaluated via regulating hypoxia inducible facor-1alpha (HIF-1alpha) and p53. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | HIF-1alpha-knockdown also sensitized A549 cells to cisplatin in hypoxia-exposed, but not in normoxia-exposed A549 cells, suggesting that hypoxia-induced cisplatin resistance partially contributes toward the upregulation of HIF-1alpha by hypoxia exposure. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | HIF-1alpha-knockdown also sensitized A549 cells to cisplatin in hypoxia-exposed, but not in normoxia-exposed A549 cells, suggesting that hypoxia-induced cisplatin resistance partially contributes toward the upregulation of HIF-1alpha by hypoxia exposure. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | HIF-1alpha-knockdown also sensitized A549 cells to cisplatin in hypoxia-exposed, but not in normoxia-exposed A549 cells, suggesting that hypoxia-induced cisplatin resistance partially contributes toward the upregulation of HIF-1alpha by hypoxia exposure. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 6 | Taken together, these results identified the exact effects of HIF-1alpha and p53 induced by hypoxia and potentially elucidated their protective effects on A549 cells against cisplatin. | Cisplatin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |