Title : Estradiol-mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKα, and miR-221.

Pub. Date : 2018 Nov

PMID : 29957877






4 Functional Relationships(s)
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1 Estradiol-mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKalpha, and miR-221. Estradiol nitric oxide synthase 2 Rattus norvegicus
2 PURPOSE: This study aimed to investigate in vivo effects of estradiol on the regulation of hepatic inducible nitric oxide synthase (iNOS) expression in the high fat (HF) diet-induced obesity. Estradiol nitric oxide synthase 2 Rattus norvegicus
3 PURPOSE: This study aimed to investigate in vivo effects of estradiol on the regulation of hepatic inducible nitric oxide synthase (iNOS) expression in the high fat (HF) diet-induced obesity. Estradiol nitric oxide synthase 2 Rattus norvegicus
4 Results show that estradiol treatment of HF rats decreased hepatic iNOS mRNA (P < 0.05) and protein expression (P < 0.01), the protein levels of p65 subunit of nuclear factor kappaB (P < 0.05) and ERalpha (P < 0.05), ERK1/2 phosphorylation (P < 0.001), and ERalpha/Src kinase association (P < 0.05). Estradiol nitric oxide synthase 2 Rattus norvegicus