Title : Anti-osteoclastic effect of caffeic acid phenethyl ester in murine macrophages depends upon the suppression of superoxide anion production through the prevention of an active-Nox1 complex formation.

Pub. Date : 2018 Aug

PMID : 29957360






1 Functional Relationships(s)
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1 This study provides evidence that the anti-osteoclastic effect of CAPE depends upon the attenuated superoxide anion production, which is closely related with interruption of an active Nox1 complex formation due to the attenuated catalytic subunit Nox1 expression resulting from suppression of the IKKbeta/IkappaBalpha/NF-kappaB and JNK/AP-1 signaling pathway and the down-regulation of the p47phox subunit translocation to the cell membrane. Superoxides mitogen-activated protein kinase 8 Mus musculus