PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29957360-10 2018 This study provides evidence that the anti-osteoclastic effect of CAPE depends upon the attenuated superoxide anion production, which is closely related with interruption of an active Nox1 complex formation due to the attenuated catalytic subunit Nox1 expression resulting from suppression of the IKKbeta/IkappaBalpha/NF-kappaB and JNK/AP-1 signaling pathway and the down-regulation of the p47phox subunit translocation to the cell membrane. Superoxides 99-115 mitogen-activated protein kinase 8 Mus musculus 332-335