Pub. Date : 2019 Jan 28
PMID : 29924730
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations. | BH 3 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Specifically, the selective BH3-mimetics ABT-199, A-1331852 and S63845, which target BCL-2, BCL-XL and MCL-1, respectively, induce comparable ultrastructural changes including mitochondrial swelling, a decrease of mitochondrial matrix density and severe loss of cristae structure. | BH 3 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |