Title : Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1.

Pub. Date : 2018 May 25

PMID : 29799788






3 Functional Relationships(s)
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1 Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 We observed that UA-induced Noxa expression was followed by a consequent decrease in Mcl-1 expression in a dose-dependent manner. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Furthermore, the results from IP studies and proximity ligation assays indicated that UA-induced Noxa colocalizes and associates with Mcl-1 to prime it for proteasomal degradation through K48-linked ubiquitination by the selective recruitment of Mcl-1 ubiquitin ligase E3, a homologous to E6-associated protein C terminus domain-containing E3 ubiquitin ligase. ursolic acid MCL1 apoptosis regulator, BCL2 family member Homo sapiens