Title : Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency.

Pub. Date : 2018 Apr 29

PMID : 29710837






1 Functional Relationships(s)
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1 Molecular dynamics (MD) simulations showed that V366M creates a “one-way valve” and suggests a mechanism for dual activities of human CYP17A1 where, after the conversion of pregnenolone to 17OH-pregnenolone, the product exits the active site and re-enters for conversion to dehydroepiandrosterone. 17-alpha-Hydroxypregnenolone cytochrome P450 family 17 subfamily A member 1 Homo sapiens