PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29710837-5 2018 Molecular dynamics (MD) simulations showed that V366M creates a “one-way valve” and suggests a mechanism for dual activities of human CYP17A1 where, after the conversion of pregnenolone to 17OH-pregnenolone, the product exits the active site and re-enters for conversion to dehydroepiandrosterone. 17-alpha-Hydroxypregnenolone 209-226 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 154-161