Pub. Date : 2018 Jul
PMID : 29684854
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of Her2-Nrf2 axis in induction of oxaliplatin resistance in colon cancer cells. | Oxaliplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | The aim of this study was to investigate the possible cross talk between Nrf2 and Her2 mediated signaling pathways in development of oxaliplatin resistance in colon cancer cells. | Oxaliplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | We first generated oxaliplatin-resistant LS174T and SW480 colon cancer cells with different Her2 expression levels by employing IC50 concentrations followed by a resting period. | Oxaliplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 4 | Inhibition of either Nrf2 or Her2 alone and in combination caused a significant increase in oxaliplatin-induced cytotoxicity and apoptosis with maximum effects in SW480/Res cells with low Her2 and Nrf2 expression levels. | Oxaliplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 5 | Inhibition of either Nrf2 or Her2 alone and in combination caused a significant increase in oxaliplatin-induced cytotoxicity and apoptosis with maximum effects in SW480/Res cells with low Her2 and Nrf2 expression levels. | Oxaliplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 6 | Altogether, our results suggest that inhibition of Nrf2 signaling in colon cancer patients with Her2 overexpression can be considered as an important strategy to overcome oxaliplatin resistance. | Oxaliplatin | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |