Title : 3D-QSAR with R: A new 3D-QSAR methodology applied to a set of DGAT1 inhibitors [corrected].

Pub. Date : 2018 Jun

PMID : 29602042






1 Functional Relationships(s)
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1 The 3D-QSAR model suggested that the substitutions of the alkyl group at the oxadiazolyl ring at the 6th position of the pyrrolo-pyridazine ring is undesirable, on the contrary, substituted phenyl ring at 7th position is responsible for the improved DGAT1 inhibitory activity. Pyrrolopyridazine diacylglycerol O-acyltransferase 1 Homo sapiens