Title : The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro.

Pub. Date : 2018 Mar 2

PMID : 29568367






1 Functional Relationships(s)
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1 Sensitivity was completely restored with specific inhibitors cyclosporine (ABCB1) and Ko143 (ABCG2): K562-Dox LD50asciminib+cyclosporine = 13 nM, K562-ABCG2 LD50asciminib+Ko143 = 15 nM (p < 0.001). Cyclosporine ATP binding cassette subfamily B member 1 Homo sapiens