Pub. Date : 2018 Apr 25
PMID : 29525432
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Marliolide inhibits skin carcinogenesis by activating NRF2/ARE to induce heme oxygenase-1. | marliolide | heme oxygenase 1 | Homo sapiens |
| 2 | In the present study, we identified marliolide as a novel inducer of HO-1 in human normal keratinocyte HaCaT cells. | marliolide | heme oxygenase 1 | Homo sapiens |
| 3 | Mechanism-based studies demonstrated that the induction of HO-1 by marliolide occurred through activation of NRF2/ARE via direct binding of marliolide to KEAP1. | marliolide | heme oxygenase 1 | Homo sapiens |
| 4 | Mechanism-based studies demonstrated that the induction of HO-1 by marliolide occurred through activation of NRF2/ARE via direct binding of marliolide to KEAP1. | marliolide | heme oxygenase 1 | Homo sapiens |
| 5 | Structure-activity relationship revealed chemical moieties of marliolide critical for induction of HO-1, which renders a support for Michael reaction as a potential mechanism of action. | marliolide | heme oxygenase 1 | Homo sapiens |