Title : Overexpression of microRNA-15 increases the chemosensitivity of colon cancer cells to 5-fluorouracil and oxaliplatin by inhibiting the nuclear factor-κB signalling pathway and inducing apoptosis.

Pub. Date : 2018 Mar

PMID : 29467857






1 Functional Relationships(s)
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1 miR-15 promoted apoptosis in colon cancer cells treated with 5-Fu and OX by inhibiting the expression of p50, which repressed the expression of B cell lymphoma-2 and B cell lymphoma-extra large; two direct target genes of nuclear factor-kappaB with anti-apoptotic functions. Fluorouracil nuclear factor kappa B subunit 1 Homo sapiens