Title : Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets.

Pub. Date : 2018 Feb 19

PMID : 29462984






2 Functional Relationships(s)
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1 Specifically, the models predict, unexpectedly, a strong effect of pharmacological inhibitors of cGMP-specific PDE5 on the cGMP/cAMP cross-talk. Cyclic AMP phosphodiesterase 5A Homo sapiens
2 In conclusion, increased NO signalling or PDE5 inhibition are attractive ways of increasing cGMP-cAMP cross-talk selectively in platelets. Cyclic AMP phosphodiesterase 5A Homo sapiens