Pub. Date : 2018 May
PMID : 29453318
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 2 | ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 3 | ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 4 | ShcA (SHC1) is one such adaptor protein that employs two phospho-tyrosine binding domains (PTB and SH2) and key phospho-tyrosine residues to promote mammary tumorigenesis. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 5 | Receptor tyrosine kinases (RTK), such as ErbB2, bind the ShcA PTB domain to promote breast tumorigenesis by engaging Grb2 downstream of the ShcA tyrosine phosphorylation sites to activate AKT/mTOR signaling. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 6 | Receptor tyrosine kinases (RTK), such as ErbB2, bind the ShcA PTB domain to promote breast tumorigenesis by engaging Grb2 downstream of the ShcA tyrosine phosphorylation sites to activate AKT/mTOR signaling. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 7 | This study mechanistically dissects how the interplay between diverse intracellular ShcA complexes impacts the tyrosine kinome to affect breast tumorigenesis.Implications: The ShcA adaptor, within distinct signaling complexes, impacts tyrosine kinase signaling, breast tumor growth, and resistance to tyrosine kinase inhibitors. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |
| 8 | This study mechanistically dissects how the interplay between diverse intracellular ShcA complexes impacts the tyrosine kinome to affect breast tumorigenesis.Implications: The ShcA adaptor, within distinct signaling complexes, impacts tyrosine kinase signaling, breast tumor growth, and resistance to tyrosine kinase inhibitors. | Tyrosine | SHC adaptor protein 1 | Homo sapiens |