Protein Name SHC adaptor protein 1
Organism Homo sapiens
Gene ID 6464
Gene Symbol


UniProt P29353 (SHC1_HUMAN)
Relationships Total Number of functionally related compound(s) : 221
Total Number of Articles : 620

SHC adaptor protein 1

Gene Summary

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

  • SHC-transforming protein 1
  • SH2 domain protein C1
  • SHC (Src homology 2 domain containing) transforming protein 1
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