Pub. Date : 2017 Dec 26
PMID : 29371942
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 2 | Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 3 | Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 4 | Computational modeling showed that quercetin exhibited an orientation favorable to nucleophilic attack in the phosphatase domain of SHP2. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 5 | The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 6 | The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 7 | The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 8 | The results suggested that quercetin potentiated the inhibitory effect of IFN-alpha on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2. | Quercetin | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |