| Protein Name | protein tyrosine phosphatase non-receptor type 11 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5781 |
| Gene Symbol | PTPN11 |
| UniProt | Q06124 (PTN11_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
376
Total Number of Articles : 732 |
Description |
protein tyrosine phosphatase non-receptor type 11 |
| Gene Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016] |
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