Protein Name protein tyrosine phosphatase non-receptor type 11
Organism Homo sapiens
Gene ID 5781
Gene Symbol


UniProt Q06124 (PTN11_HUMAN)
Relationships Total Number of functionally related compound(s) : 376
Total Number of Articles : 732

protein tyrosine phosphatase non-receptor type 11

Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]

  • tyrosine-protein phosphatase non-receptor type 11
  • SH2 domain-containing protein tyrosine phosphatase 2
  • protein-tyrosine phosphatase 1D
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