PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29371942-0	2017	Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase.	Quercetin	8-17	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	179-183	
29371942-3	2017	Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2.	Quercetin	88-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	56-60	
29371942-3	2017	Using an in vitro screening assay for new inhibitors of SHP2 phosphatase, we found that quercetin was a potent inhibitor of SHP2.	Quercetin	88-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	124-128	
29371942-4	2017	Computational modeling showed that quercetin exhibited an orientation favorable to nucleophilic attack in the phosphatase domain of SHP2.	Quercetin	35-44	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	132-136	
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	52-61	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-26	
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-26	
29371942-7	2017	The overexpression of SHP2 attenuated the effect of quercetin on IFN-alpha-stimulated STAT1 phosphorylation and antiproliferative effect, whereas the inhibition of SHP2 promoted the effect of quercetin on IFN-alpha-induced STAT1 phosphorylation and antiproliferative effect.	Quercetin	192-201	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	164-168	
29371942-8	2017	The results suggested that quercetin potentiated the inhibitory effect of IFN-alpha on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2.	Quercetin	27-36	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	176-180