Pub. Date : 2018
PMID : 29298347
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The BH3-only apoptosis agonists BAD and NOXA target BCL-2 and MCL-1 respectively and co-operate to induce apoptosis. | BH 3 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | We found that a broad range of anti-leukaemic agents-notably MCL-1 inhibitors, DNA damaging agents and FLT3 inhibitors-sensitise leukaemia cells to BAD-BH3. | BH 3 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | In conclusion, dynamic BH3 profiling is a useful mechanism-based tool for understanding and predicting co-operative lethality between drugs sensitising to BCL-2 antagonism and drugs sensitising to MCL-1 antagonism. | BH 3 | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |