Title : Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome.

Pub. Date : 2017 Nov 30

PMID : 29214238






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The activity of SHP2, like that of most PTPs, is reversibly inactivated by reactive oxygen species (ROS). Reactive Oxygen Species protein tyrosine phosphatase non-receptor type 11 Homo sapiens
2 The activity of SHP2, like that of most PTPs, is reversibly inactivated by reactive oxygen species (ROS). Reactive Oxygen Species protein tyrosine phosphatase non-receptor type 11 Homo sapiens
3 However, the molecular basis of this inactivation and the consequences of NS-related mutations in PTPN11 on ROS-mediated inhibition are poorly understood. Reactive Oxygen Species protein tyrosine phosphatase non-receptor type 11 Homo sapiens