Pub. Date : 2018 Jan 17
PMID : 29189472
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SIRT2 and Akt mediate NAD+-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia under basal conditions. | Adenosine Triphosphate | sirtuin 2 | Mus musculus |
| 2 | We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002. | Adenosine Triphosphate | sirtuin 2 | Mus musculus |
| 3 | We found that both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002. | Adenosine Triphosphate | sirtuin 2 | Mus musculus |
| 4 | Collectively, our study has suggested that SIRT2 mediates both NAD-induced and NADH-induced increases in the intracellular ATP levels of BV2 microglia by modulating Akt phosphorylation. | Adenosine Triphosphate | sirtuin 2 | Mus musculus |