Protein Name sirtuin 2
Organism Mus musculus
Gene ID 64383
Gene Symbol

Sirt2

UniProt Q8VDQ8 (SIR2_MOUSE)
Relationships Total Number of functionally related compound(s) : 95
Total Number of Articles : 120
Description

sirtuin 2

Gene Summary

Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • NAD-dependent protein deacetylase sirtuin-2
  • NAD-dependent deacetylase sirtuin-2
  • NAD-dependent protein defatty-acylase sirtuin-2
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Properties