| Protein Name | sirtuin 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 64383 |
| Gene Symbol | Sirt2 |
| UniProt | Q8VDQ8 (SIR2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
95
Total Number of Articles : 120 |
Description |
sirtuin 2 |
| Gene Summary |
Enables NAD-dependent protein lysine deacetylase activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including cellular response to caloric restriction; positive regulation of cell cycle process; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of NLRP3 inflammasome complex assembly; regulation of fat cell differentiation; and tubulin deacetylation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in several structures, including brain; liver; oocyte; sensory organ; and spinal cord. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |